Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 2/20 | 0.45 |
| ▸ | CHRM3 | P20309 | 6/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.41 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.41 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.41 |
| ▸ | HTR7 | P34969 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.41 |
| ▸ | ATR | Q13535 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SLC5A7 | Q9GZV3 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4486950 | 0.95 | EPHX2 (0.46) | EPHX2CHRM3DRD4CARM1PRMT6 | |
| SCHEMBL4480537 | 0.93 | EPHX2 (0.43) | EPHX2CHRM3DRD4CARM1PRMT6 | |
| SCHEMBL4477851 | 0.92 | ALDH1A1 (0.51) | EPHX2CHRM3ALDH1A1TP53 | |
| SCHEMBL4493985 | 0.89 | CHRM3 (0.41) | CHRM3DRD4CARM1PRMT6ALDH1A1 | |
| SCHEMBL265553 | 0.89 | CHRM3 (0.56) | CHRM3 | |
| SCHEMBL4470444 | 0.89 | CARM1 (0.48) | EPHX2CHRM3CARM1PRMT6HTR7 | |
| SCHEMBL4494146 | 0.88 | EPHX2 (0.46) | EPHX2CHRM3CARM1PRMT6HTR7 | |
| SCHEMBL4482920 | 0.88 | CHRM3 (0.45) | EPHX2CHRM3CARM1PRMT6HTR7 | |
| SCHEMBL4478408 | 0.88 | EPHX2 (0.45) | EPHX2CHRM3CARM1PRMT6HTR7 | |
| SCHEMBL4486948 | 0.87 | EPHX2 (0.44) | EPHX2DRD4CARM1PRMT6HTR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632847-B2 | Bronchodilators; treating chronic obstructive pulmonary disease or asthma; long duration of action; reduced side effects, such as dry-mouth and constipation; e.g. biphenyl-2-ylcarbamic acid 1-(2-(3-[3-(4-hydroxybenzylamino)propionylamino]benzoylamino)ethyl)piperidin-4-yl ester | THERAVANCE, INC. (US) | 2009-12-15 | — | — | US | disclosed |