Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.48 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | ITK | Q08881 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4490467 | 0.90 | HDAC6 (0.52) | MAPTCDK2GSK3AHDAC6MAPK1 | |
| SCHEMBL4480839 | 0.88 | MAPT (0.60) | MAPTCDK2GSK3AHDAC6MAPK1 | |
| SCHEMBL4495755 | 0.87 | HDAC6 (0.55) | MAPTCDK2GSK3AHDAC6MAPK1 | |
| SCHEMBL4497998 | 0.85 | HDAC6 (0.65) | MAPTCDK2GSK3AHDAC6MAPK1 | |
| SCHEMBL4483351 | 0.85 | HDAC6 (0.53) | MAPTCDK2GSK3AHDAC6MAPK1 | |
| SCHEMBL4480196 | 0.83 | FGFR1 (0.65) | HDAC6GSK3BFGFR1FGFR2FGFR3 | |
| SCHEMBL4494227 | 0.82 | HDAC6 (0.65) | CDK2GSK3AHDAC6MAPK1GSK3B | |
| SCHEMBL4480790 | 0.82 | DYRK1A (0.57) | CDK2GSK3AHDAC6GSK3B | |
| SCHEMBL4494277 | 0.82 | HDAC6 (0.68) | MAPTCDK2GSK3AHDAC6MAPK1 | |
| SCHEMBL4493562 | 0.81 | HDAC6 (0.69) | CDK2GSK3AHDAC6MAPK1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |