Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | GSK3A | P49840 | 2/20 | 0.53 |
| ▸ | CDK2 | P24941 | 1/20 | 0.53 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.51 |
| ▸ | GSK3B | P49841 | 4/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4497998 | 0.93 | HDAC6 (0.65) | HDAC6GSK3ACDK2FGFR4GSK3B | |
| SCHEMBL4494227 | 0.89 | HDAC6 (0.65) | HDAC6GSK3ACDK2GSK3BFGFR1 | |
| SCHEMBL4480839 | 0.88 | MAPT (0.60) | HDAC6NPC1RAB9AGSK3ACDK2 | |
| SCHEMBL4502571 | 0.88 | MAPK1 (0.55) | HDAC6GSK3ACDK2FGFR4GSK3B | |
| SCHEMBL4483351 | 0.87 | HDAC6 (0.53) | HDAC6NPC1RAB9AGSK3ACDK2 | |
| SCHEMBL4495224 | 0.87 | HDAC6 (0.67) | HDAC6GSK3ACDK2GSK3BFGFR1 | |
| SCHEMBL4494927 | 0.87 | HDAC6 (0.69) | HDAC6NPC1RAB9AGSK3ACDK2 | |
| SCHEMBL4480767 | 0.87 | MAPT (0.48) | HDAC6NPC1RAB9AGSK3ACDK2 | |
| SCHEMBL4494101 | 0.85 | HDAC6 (0.57) | HDAC6GSK3ACDK2GSK3BFGFR1 | |
| SCHEMBL4490916 | 0.85 | GSK3B (0.59) | HDAC6NPC1RAB9AGSK3ACDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |