Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM3 | P20309 | 4/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 8/20 | 0.46 |
| ▸ | GSK3B | P49841 | 4/20 | 0.46 |
| ▸ | GSK3A | P49840 | 2/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.44 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.44 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.44 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4482945 | 0.92 | GSK3B (0.51) | AAK1GSK3BGSK3AHDAC6 | |
| SCHEMBL4486750 | 0.90 | HDAC1 (0.59) | AAK1GSK3BGSK3AHDAC1HDAC2 | |
| SCHEMBL4499391 | 0.89 | AAK1 (0.61) | AAK1GSK3BGSK3A | |
| SCHEMBL12899166 | 0.89 | GSK3B (0.56) | AAK1GSK3BGSK3AFGFR1FGFR2 | |
| SCHEMBL12899596 | 0.87 | LCK (0.45) | CHRM3AAK1GSK3BGSK3AHDAC6 | |
| SCHEMBL12886077 | 0.87 | HDAC6 (0.51) | CHRM3AAK1GSK3BGSK3AHDAC6 | |
| SCHEMBL12886233 | 0.87 | GSK3B (0.45) | AAK1GSK3BGSK3A | |
| SCHEMBL4488374 | 0.86 | HDAC6 (0.53) | CHRM3AAK1GSK3BGSK3AHDAC1 | |
| SCHEMBL4500034 | 0.86 | GSK3B (0.58) | AAK1GSK3BGSK3AHDAC1HDAC2 | |
| SCHEMBL12899164 | 0.85 | GSK3B (0.47) | AAK1GSK3BGSK3AFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |