Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 5/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 5/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 7/20 | 0.56 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.49 |
| ▸ | GSK3A | P49840 | 2/20 | 0.47 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.45 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.45 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4488374 | 0.93 | HDAC6 (0.53) | HDAC1HDAC2HDAC8FGFR1HDAC6 | |
| SCHEMBL4480802 | 0.90 | CHRM3 (0.47) | HDAC1HDAC2HDAC8FGFR1HDAC6 | |
| SCHEMBL4492892 | 0.88 | HDAC6 (0.56) | HDAC1HDAC2HDAC8FGFR1HDAC6 | |
| SCHEMBL4499391 | 0.88 | AAK1 (0.61) | GSK3AGSK3BAAK1 | |
| SCHEMBL12899166 | 0.87 | GSK3B (0.56) | FGFR1FGFR2FGFR3GSK3AGSK3B | |
| SCHEMBL4482945 | 0.87 | GSK3B (0.51) | HDAC6GSK3AGSK3BAAK1 | |
| SCHEMBL12886233 | 0.86 | GSK3B (0.45) | GSK3AGSK3BAAK1TLR9TLR8 | |
| SCHEMBL12886077 | 0.86 | HDAC6 (0.51) | HDAC6GSK3AGSK3BAAK1 | |
| SCHEMBL4501959 | 0.85 | FGFR1 (0.59) | HDAC1HDAC2HDAC8FGFR1HDAC6 | |
| SCHEMBL4482265 | 0.85 | HDAC1 (0.58) | HDAC1HDAC2HDAC8FGFR1HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |