Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 17/20 | 0.54 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.49 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4564455 | 0.81 | NOTUM (0.58) | NOTUMKEAP1CYP19A1 | |
| SCHEMBL13735664 | 0.81 | NOTUM (0.58) | NOTUMKEAP1CYP19A1 | |
| SCHEMBL2359098 | 0.79 | NOTUM (0.54) | NOTUMKEAP1CYP19A1 | |
| SCHEMBL5612825 | 0.77 | NOTUM (0.53) | NOTUMKEAP1CYP19A1 | |
| SCHEMBL22325390 | 0.77 | NOTUM (0.53) | NOTUMKEAP1CYP19A1 | |
| SCHEMBL4457296 | 0.77 | NOTUM (0.49) | NOTUMKEAP1 | |
| SCHEMBL10447781 | 0.76 | NOTUM (0.78) | NOTUMKEAP1CYP19A1 | |
| SCHEMBL1696198 | 0.76 | NOTUM (0.47) | NOTUMKEAP1 | |
| SCHEMBL17422567 | 0.76 | NOTUM (0.51) | NOTUMKEAP1 | |
| SCHEMBL5602626 | 0.76 | NOTUM (0.47) | NOTUMKEAP1CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2034996-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | Synta Pharmaceuticals Corporation (US) | 2009-03-18 | — | — | EP | claimed |
| WO-2007139955-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2007-12-06 | — | — | WO | claimed |
| EP-2034996-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | Synta Pharmaceuticals Corporation (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007139955-A2 | TRIAZOLE COMPOUNDS THAT MODULATE HSP90 ACTIVITY | SYNTA PHARMACEUTICALS CORP. (US) | 2007-12-06 | — | — | WO | disclosed |