Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.60 |
| ▸ | GSK3B | P49841 | 5/20 | 0.51 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.48 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4485340 | 0.94 | AAK1 (0.62) | AAK1GSK3BBRAFKMT2AMEN1 | |
| SCHEMBL4484161 | 0.89 | AAK1 (0.64) | AAK1GSK3B | |
| SCHEMBL4494923 | 0.89 | AAK1 (0.64) | AAK1GSK3BHDAC1HDAC2HDAC8 | |
| SCHEMBL4492082 | 0.88 | AAK1 (0.63) | AAK1GSK3BHDAC1HDAC2HDAC8 | |
| SCHEMBL4488792 | 0.88 | AAK1 (0.68) | AAK1GSK3BMKNK1MKNK2FGFR2 | |
| SCHEMBL4479634 | 0.87 | AAK1 (0.67) | AAK1GSK3B | |
| SCHEMBL4492570 | 0.86 | GSK3B (0.59) | GSK3BKMT2AMEN1ALDH1A1ROCK2 | |
| SCHEMBL4491352 | 0.86 | AAK1 (0.66) | AAK1GSK3BMKNK1MKNK2FGFR2 | |
| SCHEMBL4487369 | 0.85 | HDAC1 (0.61) | GSK3BKMT2AMEN1HDAC1HDAC2 | |
| SCHEMBL4480524 | 0.84 | AAK1 (0.58) | AAK1GSK3BSMN1; SMN2PTGIRFGFR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |