Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 13/20 | 0.63 |
| ▸ | GSK3B | P49841 | 2/20 | 0.48 |
| ▸ | GAK | O14976 | 7/20 | 0.47 |
| ▸ | STK16 | O75716 | 7/20 | 0.47 |
| ▸ | BMP2K | Q9NSY1 | 7/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.47 |
| ▸ | RIOK3 | O14730 | 1/20 | 0.47 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.47 |
| ▸ | CDKL2 | Q92772 | 1/20 | 0.47 |
| ▸ | RIOK1 | Q9BRS2 | 1/20 | 0.47 |
| ▸ | MYLK2 | Q9H1R3 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.46 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4491352 | 0.94 | AAK1 (0.66) | AAK1GSK3BGAKSTK16BMP2K | |
| SCHEMBL4494923 | 0.91 | AAK1 (0.64) | AAK1GSK3BGAKSTK16BMP2K | |
| SCHEMBL4484161 | 0.91 | AAK1 (0.64) | AAK1GSK3BGAKSTK16BMP2K | |
| SCHEMBL4488792 | 0.90 | AAK1 (0.68) | AAK1GSK3BGAKSTK16BMP2K | |
| SCHEMBL4479634 | 0.89 | AAK1 (0.67) | AAK1GSK3BGAKSTK16BMP2K | |
| SCHEMBL4483440 | 0.88 | AAK1 (0.60) | AAK1GSK3BMKNK1MKNK2FGFR2 | |
| SCHEMBL4505096 | 0.87 | GSK3B (0.51) | AAK1GSK3BFGFR2FGFR3HDAC1 | |
| SCHEMBL4485340 | 0.86 | AAK1 (0.62) | AAK1GSK3BGAKSTK16BMP2K | |
| SCHEMBL4492939 | 0.84 | GSK3B (0.60) | AAK1GSK3BHDAC1HDAC2HDAC8 | |
| SCHEMBL4503182 | 0.83 | AAK1 (0.55) | AAK1GSK3BGAKSTK16BMP2K |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |