Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR3 | Q9UBY5 | 11/20 | 0.51 |
| ▸ | LPAR2 | Q9HBW0 | 7/20 | 0.51 |
| ▸ | LPAR1 | Q92633 | 6/20 | 0.51 |
| ▸ | P2RY10 | O00398 | 1/20 | 0.47 |
| ▸ | LPAR5 | Q9H1C0 | 1/20 | 0.44 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12354844 | 0.81 | LPAR1 (0.59) | LPAR3LPAR2LPAR1LPAR5MEN1 | |
| SCHEMBL28798792 | 0.79 | LPAR3 (0.39) | LPAR3LPAR2LPAR1MEN1KMT2A | |
| SCHEMBL29026510 | 0.78 | LPAR3 (0.84) | LPAR3LPAR2LPAR1P2RY10LPAR5 | |
| SCHEMBL29026467 | 0.78 | LPAR3 (0.84) | LPAR3LPAR2LPAR1P2RY10LPAR5 | |
| SCHEMBL18444519 | 0.78 | LPAR3 (0.84) | LPAR3LPAR2LPAR1P2RY10LPAR5 | |
| SCHEMBL28783278 | 0.78 | CYP3A4 (0.50) | LPAR3LPAR2LPAR1 | |
| SCHEMBL4483106 | 0.78 | LPAR3 (0.84) | LPAR3LPAR2LPAR1P2RY10LPAR5 | |
| SCHEMBL4247095 | 0.78 | LPAR3 (0.84) | LPAR3LPAR2LPAR1P2RY10LPAR5 | |
| SCHEMBL2379995 | 0.78 | LPAR3 (0.84) | LPAR3LPAR2LPAR1P2RY10LPAR5 | |
| SCHEMBL6810040 | 0.78 | LPAR3 (0.84) | LPAR3LPAR2LPAR1P2RY10LPAR5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7517858-B1 | Prodrugs of pharmaceuticals with improved bioavailability | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2009-04-14 | — | — | US | disclosed |
| EP-0837630-B1 | PRODRUGS OF PHARMACEUTICALS WITH IMPROVED BIOAVAILABILITY | HOSTETLER KARL Y (US) | 2007-12-26 | — | — | EP | disclosed |
| EP-0837630-A4 | PRODRUGS OF PHARMACEUTICALS WITH IMPROVED BIOAVAILABILITY | UNIV CALIFORNIA (US) | 1998-11-25 | — | — | EP | disclosed |
| EP-0837630-A1 | PRODRUGS OF PHARMACEUTICALS WITH IMPROVED BIOAVAILABILITY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1998-04-29 | — | — | EP | disclosed |
| WO-1996039831-A1 | PRODRUGS OF PHARMACEUTICALS WITH IMPROVED BIOAVAILABILITY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1996-12-19 | — | — | WO | disclosed |