Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.58 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | GSK3B | P49841 | 15/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
| ▸ | GSK3A | P49840 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4477055 | 0.89 | GSK3B (0.65) | AAK1KDRGSK3BHDAC6GSK3A | |
| SCHEMBL4495082 | 0.88 | HDAC6 (0.66) | AAK1KDRGSK3BHDAC6GSK3A | |
| SCHEMBL4494393 | 0.86 | GSK3B (0.68) | AAK1GSK3BHDAC6GSK3APIK3CD | |
| SCHEMBL4498057 | 0.86 | AAK1 (0.52) | AAK1KDRGSK3BHDAC6GSK3A | |
| SCHEMBL4499351 | 0.86 | DYRK1A (0.63) | AAK1KDRGSK3BHDAC6GSK3A | |
| SCHEMBL4493797 | 0.85 | AAK1 (0.58) | AAK1KDRGSK3BHDAC6GSK3A | |
| SCHEMBL4502197 | 0.85 | AAK1 (0.64) | AAK1GSK3BHDAC6GSK3ACYP1A2 | |
| SCHEMBL4482280 | 0.85 | AAK1 (0.58) | AAK1GSK3BHDAC6GSK3APIK3CD | |
| SCHEMBL4491027 | 0.85 | GSK3B (0.69) | AAK1KDRGSK3BGSK3ACYP1A2 | |
| SCHEMBL4489062 | 0.84 | HDAC6 (0.65) | AAK1GSK3BHDAC6CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |