Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 6/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.61 |
| ▸ | GSK3B | P49841 | 7/20 | 0.51 |
| ▸ | GSK3A | P49840 | 2/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.48 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.46 |
| ▸ | PLK4 | O00444 | 1/20 | 0.45 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.45 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.45 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | CDK2 | P24941 | 1/20 | 0.45 |
| ▸ | MARK3 | P27448 | 1/20 | 0.45 |
| ▸ | FLT4 | P35916 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4483610 | 0.91 | GSK3B (0.64) | HDAC6HDAC1HDAC2HDAC8GSK3B | |
| SCHEMBL4497956 | 0.87 | GSK3B (0.52) | HDAC6HDAC1HDAC2HDAC8GSK3B | |
| SCHEMBL4480354 | 0.87 | GSK3B (0.60) | HDAC6HDAC1HDAC2HDAC8GSK3B | |
| SCHEMBL4502518 | 0.86 | GSK3B (0.65) | HDAC6HDAC1HDAC2HDAC8GSK3B | |
| SCHEMBL4477054 | 0.86 | HDAC6 (0.58) | HDAC6HDAC1HDAC2HDAC8GSK3B | |
| SCHEMBL4482990 | 0.85 | GSK3B (0.65) | HDAC6HDAC1HDAC2HDAC8GSK3B | |
| SCHEMBL4486394 | 0.84 | HDAC6 (0.66) | HDAC6HDAC1HDAC2HDAC8GSK3B | |
| SCHEMBL4494521 | 0.84 | GSK3B (0.49) | HDAC6HDAC1HDAC2HDAC8GSK3B | |
| SCHEMBL4481808 | 0.83 | HDAC6 (0.59) | HDAC6HDAC1HDAC2HDAC8GSK3B | |
| SCHEMBL4492160 | 0.82 | HDAC6 (0.66) | HDAC6HDAC1HDAC2HDAC8GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |