Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.53 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.53 |
| ▸ | ACHE | P22303 | 3/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.50 |
| ▸ | GSK3A | P49840 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4490073 | 0.91 | GSK3B (0.56) | GSK3BHDAC1HDAC2HDAC8 | |
| SCHEMBL4494322 | 0.87 | GSK3B (0.56) | GSK3BAAK1ACHEHDAC1HDAC2 | |
| SCHEMBL4486782 | 0.86 | HDAC1 (0.68) | GSK3BAAK1ACHEHDAC1HDAC2 | |
| SCHEMBL4485400 | 0.85 | GSK3B (0.65) | GSK3BAAK1GSK3A | |
| SCHEMBL4489015 | 0.85 | GSK3B (0.64) | GSK3BAAK1GSK3A | |
| SCHEMBL4490672 | 0.84 | GSK3B (0.74) | GSK3B | |
| SCHEMBL4487690 | 0.84 | HDAC1 (0.56) | GSK3BAAK1ACHEHDAC1HDAC2 | |
| SCHEMBL4483953 | 0.83 | GSK3B (0.65) | GSK3BAAK1GSK3A | |
| SCHEMBL4495973 | 0.83 | GSK3B (0.71) | GSK3BAAK1GSK3A | |
| SCHEMBL4484379 | 0.83 | GSK3B (0.58) | GSK3BHDAC1HDAC2HDAC8HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |