Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.56 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 3/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | GSK3A | P49840 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4493364 | 0.90 | GSK3B (0.59) | GSK3BHDAC1HDAC2HDAC8GSK3A | |
| SCHEMBL4506175 | 0.89 | AAK1 (0.58) | GSK3BAAK1ACHEMAPK1GSK3A | |
| SCHEMBL4486782 | 0.88 | HDAC1 (0.68) | GSK3BAAK1ACHEHDAC1HDAC2 | |
| SCHEMBL4484157 | 0.87 | GSK3B (0.53) | GSK3BAAK1ACHEHDAC1HDAC2 | |
| SCHEMBL4487690 | 0.87 | HDAC1 (0.56) | GSK3BAAK1ACHEHDAC1HDAC2 | |
| SCHEMBL4486080 | 0.85 | GSK3B (0.66) | GSK3BAAK1ACHEGSK3A | |
| SCHEMBL4479320 | 0.85 | AAK1 (0.64) | GSK3BAAK1ACHEMAPK1GSK3A | |
| SCHEMBL4497986 | 0.85 | GSK3B (0.69) | GSK3BAAK1GSK3A | |
| SCHEMBL4485536 | 0.85 | HDAC6 (0.58) | GSK3BAAK1ACHEMAPK1GSK3A | |
| SCHEMBL4485396 | 0.82 | GSK3B (0.69) | GSK3BAAK1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |