Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 16/20 | 0.68 |
| ▸ | CDK4 | P11802 | 6/20 | 0.68 |
| ▸ | CDK1 | P06493 | 3/20 | 0.58 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | IKBKB | O14920 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4818566 | 0.81 | CDK2 (1.00) | CDK2CDK4CDK1 | |
| SCHEMBL5108640 | 0.80 | CDK2 (0.81) | CDK2CDK4CDK1 | |
| SCHEMBL5092316 | 0.80 | CDK2 (1.00) | CDK2CDK4CDK1 | |
| SCHEMBL5095501 | 0.80 | CDK2 (0.80) | CDK2CDK4CDK1 | |
| SCHEMBL5105389 | 0.80 | CDK2 (0.72) | CDK2CDK4CDK1SYKIKBKB | |
| SCHEMBL23752538 | 0.79 | CDK2 (1.00) | CDK2CDK4CDK1 | |
| SCHEMBL5098635 | 0.79 | CDK2 (0.79) | CDK2CDK4CDK1 | |
| SCHEMBL6410272 | 0.78 | CDK2 (0.87) | CDK2CDK4CDK1 | |
| SCHEMBL6244692 | 0.78 | CDK2 (0.78) | CDK2CDK4CDK1IKBKB | |
| SCHEMBL27584963 | 0.78 | CDK2 (1.00) | CDK2CDK4CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7579344-B2 | Pyrimidine derivatives possessing cell-cycle inhibitors activity | ASTRAZENECA AB (SE) | 2009-08-25 | — | — | US | disclosed |