Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 18/20 | 0.78 |
| ▸ | CDK1 | P06493 | 3/20 | 0.76 |
| ▸ | CDK4 | P11802 | 6/20 | 0.69 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | IKBKB | O14920 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6245840 | 0.95 | CDK2 (0.76) | CDK2CDK1CDK4IGF1RIKBKB | |
| SCHEMBL6240851 | 0.90 | CDK2 (0.82) | CDK2CDK1CDK4IGF1RIKBKB | |
| SCHEMBL27584963 | 0.86 | CDK2 (1.00) | CDK2CDK1CDK4IGF1R | |
| SCHEMBL6242590 | 0.85 | CDK2 (0.71) | CDK2CDK1CDK4IKBKB | |
| SCHEMBL4818566 | 0.82 | CDK2 (1.00) | CDK2CDK1CDK4 | |
| SCHEMBL5108640 | 0.81 | CDK2 (0.81) | CDK2CDK1CDK4 | |
| SCHEMBL28941593 | 0.81 | CDK2 (1.00) | CDK2CDK1CDK4IGF1R | |
| SCHEMBL6243416 | 0.81 | CDK2 (0.66) | CDK2CDK1CDK4IGF1R | |
| SCHEMBL5095501 | 0.80 | CDK2 (0.80) | CDK2CDK1CDK4 | |
| SCHEMBL5092316 | 0.80 | CDK2 (1.00) | CDK2CDK1CDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1362050-B1 | PYRIMIDINE DERIVATIVES FOR INHIBITION OF CELL-PROLIFERATION | ASTRAZENECA AB (SE) | 2005-02-02 | — | — | EP | claimed |