Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.56 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.56 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.56 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.56 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.56 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.56 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.56 |
| ▸ | PLIN1 | O60240 | 2/20 | 0.56 |
| ▸ | RECQL | P46063 | 2/20 | 0.56 |
| ▸ | PLIN5 | Q00G26 | 2/20 | 0.56 |
| ▸ | ABHD5 | Q8WTS1 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | TNKS | O95271 | 1/20 | 0.56 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.56 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.56 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.56 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.56 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26102 | 0.89 | — | — | |
| SCHEMBL26103 | 0.89 | — | — | |
| SCHEMBL12992402 | 0.89 | — | — | |
| Maleic Acid SCHEMBL8348914 | 0.89 | HDAC3 (0.68) | MAPTHDAC1LMNAHDAC3HDAC4 | |
| Maleic Acid SCHEMBL8348912 | 0.89 | HDAC3 (0.68) | MAPTHDAC1LMNAHDAC3HDAC4 | |
| (Z)-1,2-Diphenylethene SCHEMBL29141136 | 0.87 | MAOB (0.59) | MAOBMAOACYP19A1TRPA1RELA | |
| Phosphine SCHEMBL29272693 | 0.87 | MAOB (0.55) | MAPTHDAC1LMNAHDAC3HDAC4 | |
| Hydrochloric Acid SCHEMBL2024092 | 0.87 | MAOB (0.55) | MAPTHDAC1LMNAHDAC3HDAC4 | |
| SCHEMBL3473868 | 0.87 | MAOB (0.55) | MAPTHDAC1LMNAHDAC3HDAC4 | |
| Bromide SCHEMBL28992232 | 0.87 | MAOB (0.55) | MAPTHDAC1LMNAHDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090061517-A1 | Cell culture apparatus and methods of making and using same | UNIVERSITY OF GEORGIA RESEARCH RESEARCH CENTER | 2009-03-05 | — | — | US | disclosed |