Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 14/20 | 0.46 |
| ▸ | HTR2B | P41595 | 14/20 | 0.46 |
| ▸ | HTR2A | P28223 | 10/20 | 0.46 |
| ▸ | P2RX7 | Q99572 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GLA | P06280 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4477560 | 0.90 | HTR2C (0.42) | HTR2CHTR2BHTR2AP2RX7KDM4E | |
| SCHEMBL4477564 | 0.90 | HTR2C (0.42) | HTR2CHTR2BHTR2AP2RX7KDM4E | |
| SCHEMBL4465357 | 0.88 | HTR2C (0.47) | HTR2CHTR2BHTR2A | |
| SCHEMBL4483518 | 0.86 | HTR2C (0.47) | HTR2CHTR2BHTR2AP2RX7 | |
| SCHEMBL4482435 | 0.86 | HTR2C (0.43) | HTR2CHTR2BHTR2AP2RX7 | |
| SCHEMBL13763031 | 0.86 | HTR2C (0.47) | HTR2CHTR2BHTR2AP2RX7KDM4E | |
| SCHEMBL4465118 | 0.84 | HTR2C (0.61) | HTR2CHTR2BHTR2A | |
| SCHEMBL4467242 | 0.82 | HTR2C (0.43) | HTR2CHTR2BHTR2AP2RX7 | |
| SCHEMBL13756862 | 0.81 | HTR2C (0.69) | HTR2CHTR2BHTR2A | |
| SCHEMBL4467969 | 0.80 | HTR2C (0.44) | HTR2CHTR2BHTR2AP2RX7KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7572805-B2 | Pyrrolo(oxo)isoquinolines as 5HT ligands | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-08-11 | — | — | US | disclosed |
| US-20060014777-A1 | Pyrrolo(oxo)isoquinolines as 5HT ligands | BRISTOL-MYERS SQUIBB COMPANY | 2006-01-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060014777-A1 | Pyrrolo(oxo)isoquinolines as 5HT ligands | HTR2B, OPRD1, HTR1B | HTR2C 17/4885HTR2B 1/4885HTR2A 31/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.