Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 7/20 | 0.41 |
| ▸ | BRAF | P15056 | 8/20 | 0.39 |
| ▸ | RAF1 | P04049 | 6/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | PLK4 | O00444 | 1/20 | 0.38 |
| ▸ | CIT | O14578 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | MUSK | O15146 | 1/20 | 0.38 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.38 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.38 |
| ▸ | MLNR | O43193 | 1/20 | 0.38 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.38 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.38 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.38 |
| ▸ | PDE6D | O43924 | 1/20 | 0.38 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.38 |
| ▸ | STK10 | O94804 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4480053 | 0.88 | RET (0.57) | RETKDRBRAFRAF1MEN1 | |
| SCHEMBL4467857 | 0.84 | RET (0.51) | RETKDRBRAFRAF1MEN1 | |
| SCHEMBL4476011 | 0.81 | RET (0.43) | RETKDRBRAFRAF1MEN1 | |
| SCHEMBL4467597 | 0.79 | RAF1 (0.57) | RETKDRBRAFRAF1MEN1 | |
| SCHEMBL4485728 | 0.79 | RET (0.43) | RETKDRBRAFRAF1PLK4 | |
| SCHEMBL4463605 | 0.78 | LMNA (0.46) | RETKDRBRAFRAF1CSF1R | |
| SCHEMBL4463621 | 0.77 | RET (0.55) | RETKDRBRAFRAF1MEN1 | |
| SCHEMBL4473226 | 0.77 | KDR (0.38) | RETKDRBRAFRAF1MET | |
| SCHEMBL4470287 | 0.76 | KDR (0.50) | RETKDRBRAFRAF1PLK4 | |
| SCHEMBL4463609 | 0.76 | RAF1 (0.51) | RETKDRBRAFRAF1PLK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070149594-A1 | Pyrrole derivatives | MERCK PATENT GMBH (DE) | 2007-06-28 | — | — | US | claimed |
| US-7598274-B2 | N-methyl-4-{4-[5-(4-chloro-3-trifluoromethylphenylcarbamoyl)-1H-pyrrol-3-yl]-phenoxy}pyridine-2-carboxamide; Raf kinases inhibitors | MERCK PATENT GMBH (DE) | 2009-10-06 | — | — | US | disclosed |
| US-20070149594-A1 | Pyrrole derivatives | MERCK PATENT GMBH (DE) | 2007-06-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070149594-A1 | Pyrrole derivatives | RAF1, BRAF, ARAF | RET 36/4885KDR 2076/4885BRAF 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.