Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.61 |
| ▸ | GSK3B | P49841 | 3/20 | 0.52 |
| ▸ | GSK3A | P49840 | 1/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.52 |
| ▸ | CCR3 | P51677 | 2/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | FAAH | O00519 | 2/20 | 0.48 |
| ▸ | ACP1 | P24666 | 1/20 | 0.48 |
| ▸ | MGLL | Q99685 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4480993 | 0.93 | HDAC1 (0.59) | MEN1KMT2ASMN1; SMN2GSK3BGSK3A | |
| SCHEMBL4487348 | 0.85 | HDAC6 (0.58) | GSK3BGSK3AHDAC6HDAC1HDAC2 | |
| SCHEMBL4484349 | 0.85 | HDAC6 (0.58) | GSK3BGSK3AHDAC6HDAC1HDAC2 | |
| SCHEMBL4479967 | 0.84 | GSK3B (0.60) | MEN1KMT2ASMN1; SMN2GSK3BGSK3A | |
| SCHEMBL4482513 | 0.83 | HDAC6 (0.60) | GSK3BGSK3AHDAC6HDAC1HDAC2 | |
| SCHEMBL4483361 | 0.83 | HDAC6 (0.62) | SMN1; SMN2GSK3BGSK3AHDAC6HDAC1 | |
| SCHEMBL4494882 | 0.82 | HDAC6 (0.61) | SMN1; SMN2GSK3BGSK3AHDAC6HDAC1 | |
| SCHEMBL4489355 | 0.81 | HDAC6 (0.60) | GSK3BGSK3AHDAC6HDAC1HDAC2 | |
| SCHEMBL4491320 | 0.81 | HDAC6 (0.59) | GSK3BGSK3AHDAC6HDAC1HDAC2 | |
| SCHEMBL4487834 | 0.80 | CYP1A2 (0.54) | KMT2ASMN1; SMN2GSK3AHDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |