Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 17/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4506175 | 0.90 | AAK1 (0.58) | GSK3BAAK1 | |
| SCHEMBL4493364 | 0.89 | GSK3B (0.59) | GSK3BCYP1A2HDAC1HDAC2HDAC8 | |
| SCHEMBL4500078 | 0.88 | GSK3B (0.57) | GSK3BCYP1A2 | |
| SCHEMBL4503133 | 0.87 | GSK3B (0.70) | GSK3BCYP1A2AAK1HDAC1HDAC2 | |
| SCHEMBL4497780 | 0.86 | GSK3B (0.60) | GSK3BCYP1A2 | |
| SCHEMBL4479144 | 0.86 | GSK3B (0.71) | GSK3BCYP1A2AAK1HDAC1HDAC2 | |
| SCHEMBL4500388 | 0.85 | GSK3B (0.56) | GSK3BCYP1A2HDAC1HDAC2HDAC8 | |
| SCHEMBL4505382 | 0.85 | CYP1A2 (0.58) | GSK3BCYP1A2AAK1HDAC1HDAC2 | |
| SCHEMBL4500329 | 0.84 | GSK3B (0.68) | GSK3BCYP1A2AAK1HDAC1HDAC2 | |
| SCHEMBL4502352 | 0.84 | HDAC1 (0.70) | GSK3BCYP1A2HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |