Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 12/20 | 0.68 |
| ▸ | GSK3A | P49840 | 2/20 | 0.68 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.55 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.53 |
| ▸ | GAK | O14976 | 1/20 | 0.53 |
| ▸ | STK16 | O75716 | 1/20 | 0.53 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4487872 | 0.91 | GSK3B (0.71) | GSK3BGSK3ACYP1A2HDAC1HDAC2 | |
| SCHEMBL4484072 | 0.90 | GSK3B (0.70) | GSK3BGSK3ACYP1A2HDAC1HDAC2 | |
| SCHEMBL4479144 | 0.90 | GSK3B (0.71) | GSK3BGSK3ACYP1A2HDAC1HDAC2 | |
| SCHEMBL4505382 | 0.87 | CYP1A2 (0.58) | GSK3BGSK3ACYP1A2HDAC1HDAC2 | |
| SCHEMBL4504357 | 0.87 | GSK3B (0.68) | GSK3BGSK3ACYP1A2HDAC1HDAC2 | |
| SCHEMBL4498585 | 0.86 | GSK3B (0.64) | GSK3BGSK3AHDAC1HDAC2HDAC8 | |
| SCHEMBL4502352 | 0.86 | HDAC1 (0.70) | GSK3BGSK3ACYP1A2HDAC1HDAC2 | |
| SCHEMBL4485453 | 0.85 | HDAC1 (0.68) | GSK3BGSK3ACYP1A2HDAC1HDAC2 | |
| SCHEMBL4503133 | 0.85 | GSK3B (0.70) | GSK3BGSK3ACYP1A2HDAC1HDAC2 | |
| SCHEMBL4486136 | 0.84 | GSK3B (0.54) | GSK3BCYP1A2HDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |