Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | CTSD | P07339 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 3/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4512108 | 0.87 | GAA (0.43) | TSHRALDH1A1MAPK1CYP2C19CYP3A4 | |
| SCHEMBL4512106 | 0.86 | CYP1A2 (0.36) | CYP1A2KMT2ACTSDBACE1ALDH1A1 | |
| SCHEMBL12945401 | 0.86 | CYP3A4 (0.35) | CYP1A2KMT2ACTSDBACE1TSHR | |
| SCHEMBL16994751 | 0.85 | TSHR (0.41) | CYP1A2KMT2ACTSDBACE1TSHR | |
| SCHEMBL3675984 | 0.81 | TSHR (0.40) | CYP1A2KMT2ACTSDBACE1TSHR | |
| SCHEMBL4402799 | 0.80 | TSHR (0.39) | CYP1A2KMT2ACTSDBACE1TSHR | |
| SCHEMBL27713723 | 0.79 | TSHR (0.38) | CYP1A2KMT2ACTSDBACE1TSHR | |
| SCHEMBL13560163 | 0.76 | ALDH1A1 (0.50) | CYP1A2TSHRSMN1; SMN2ALDH1A1HTT | |
| SCHEMBL4508419 | 0.76 | ALDH1A1 (0.48) | TSHRSMN1; SMN2ALDH1A1MAPK1CYP3A4 | |
| SCHEMBL24449558 | 0.76 | TSHR (0.36) | CYP1A2KMT2ACTSDBACE1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | PORTOLA PHARMACEUTICALS, INC. (US) | 2012-05-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120108566-A1 | NICOTINAMIDES AS JAK KINASE MODULATORS | JAK2, JAK1, NADK | CYP1A2 802/4885KMT2A 1713/4885CTSD 3845/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.