Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 19/20 | 0.76 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4479634 | 0.86 | AAK1 (0.67) | GSK3BAAK1CYP1A2 | |
| SCHEMBL4493121 | 0.86 | GSK3B (1.00) | GSK3BCYP1A2 | |
| SCHEMBL31060453 | 0.86 | GSK3B (1.00) | GSK3BCYP1A2 | |
| SCHEMBL31060134 | 0.85 | GSK3B (1.00) | GSK3BAAK1CYP1A2 | |
| SCHEMBL6485118 | 0.85 | GSK3B (1.00) | GSK3BAAK1CYP1A2 | |
| SCHEMBL4484161 | 0.85 | AAK1 (0.64) | GSK3BAAK1CYP1A2 | |
| SCHEMBL4499076 | 0.84 | GSK3B (0.83) | GSK3BCYP1A2 | |
| SCHEMBL12886082 | 0.83 | AAK1 (0.66) | GSK3BAAK1CYP1A2 | |
| SCHEMBL4488792 | 0.83 | AAK1 (0.68) | GSK3BAAK1CYP1A2 | |
| SCHEMBL4497459 | 0.83 | GSK3B (0.69) | GSK3BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |