Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 13/20 | 0.69 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.61 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.61 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4489942 | 0.86 | HDAC1 (0.79) | GSK3BCYP1A2HDAC1HDAC2HDAC8 | |
| SCHEMBL4500438 | 0.86 | GSK3B (0.74) | GSK3BCYP1A2HDAC1HDAC2HDAC8 | |
| SCHEMBL4498183 | 0.85 | GSK3B (0.78) | GSK3BCYP1A2 | |
| SCHEMBL4504265 | 0.84 | GSK3B (0.58) | GSK3BCYP1A2HDAC1HDAC2HDAC8 | |
| SCHEMBL4505382 | 0.83 | CYP1A2 (0.58) | GSK3BCYP1A2HDAC1HDAC2HDAC8 | |
| SCHEMBL4486353 | 0.83 | GSK3B (0.76) | GSK3BCYP1A2 | |
| SCHEMBL4496059 | 0.83 | GSK3B (0.65) | GSK3BCYP1A2HDAC1HDAC2HDAC8 | |
| SCHEMBL31060453 | 0.82 | GSK3B (1.00) | GSK3BCYP1A2HDAC1HDAC2HDAC8 | |
| SCHEMBL4493121 | 0.82 | GSK3B (1.00) | GSK3BCYP1A2HDAC1HDAC2HDAC8 | |
| SCHEMBL4479787 | 0.81 | FGFR1 (0.73) | GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |