Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.54 |
| ▸ | PTGER3 | P43115 | 1/20 | 0.48 |
| ▸ | P2RX7 | Q99572 | 8/20 | 0.45 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.42 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4478413 | 0.83 | MAPK14 (0.56) | MAPK14PTGER3KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL3524830 | 0.83 | MAPK14 (0.47) | MAPK14PTGER3P2RX7BRAFTP53 | |
| SCHEMBL4477737 | 0.82 | MAPK14 (0.50) | MAPK14PTGER3TP53GAAKDM4E | |
| SCHEMBL4466743 | 0.78 | MAPK14 (0.60) | MAPK14PTGER3KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL4474073 | 0.78 | MAPK14 (0.57) | MAPK14PTGER3KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL4389631 | 0.76 | ALDH1A1 (0.55) | MAPK14KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL4378463 | 0.74 | MAPK14 (0.64) | MAPK14KDM4EALDH1A1L3MBTL1 | |
| SCHEMBL4392919 | 0.73 | MAPK14 (0.89) | MAPK14KDM4EALDH1A1 | |
| SCHEMBL4489729 | 0.73 | MAPK14 (0.75) | MAPK14PTGER3P2RX7TP53KDM4E | |
| SCHEMBL4477534 | 0.73 | MAPK14 (0.82) | MAPK14PTGER3P2RX7TP53KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040058964-A1 | Substituted pyridinones | PHARMACIA LLC | 2004-03-25 | — | — | US | claimed |
| US-7629363-B2 | antiinflammatory agent for treating asthma and chronic pulmonary inflammatory disease | PFIZER INC (US) | 2009-12-08 | — | — | US | disclosed |
| US-7067540-B2 | Substituted pyridinones | PHARMACIA CORPORATION (US) | 2006-06-27 | — | — | US | disclosed |
| US-20050176775-A1 | Substituted pyridinones | PHARMACIA CORPORATION | 2005-08-11 | — | — | US | disclosed |
| US-20040058964-A1 | Substituted pyridinones | PHARMACIA LLC | 2004-03-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040058964-A1 | Substituted pyridinones | MAPK1, MAPK6, MAPK7 | MAPK14 41/4885PTGER3 910/4885P2RX7 205/4885 |
| US-20050176775-A1 | Substituted pyridinones | MAPK1, MAPK6, MAP3K6 | MAPK14 53/4885PTGER3 499/4885P2RX7 81/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.