SCHEMBL448720

SCHEMBL448720

O=CC=CN1CCCCC1

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3541272 1.00 HSD17B10 (0.31) HSD17B10SMN1; SMN2
SCHEMBL20752398 0.97
SCHEMBL644462 0.97
SCHEMBL8531022 0.89 ALDH1A1 (0.33)
SCHEMBL8531017 0.89 ALDH1A1 (0.33)
SCHEMBL8529793 0.86 ALDH1A1 (0.35)
SCHEMBL8529790 0.86 ALDH1A1 (0.35)
SCHEMBL22440292 0.76 CA12 (0.30)
SCHEMBL22282962 0.76
SCHEMBL14582189 0.76 RECQL (0.48) HSD17B10SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 100 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101573640-B Interference film with acrylamide coating and method for producing same 3M INNOVATIVE PROPERTIES CO 2013-11-13 CN claimed
US-8120854-B2 Substituted acrylamide polymer disposed between reflective layers; bonding strength; document counterfeiting prevention 3M INNOVATIVE PROPERTIES COMPANY (US) 2012-02-21 US claimed
EP-2126616-A1 INTERFERENCE FILMS HAVING ACRYLAMIDE LAYER AND METHOD OF MAKING SAME 3M Innovative Properties Company (US) 2009-12-02 EP claimed
WO-2008082935-A1 INTERFERENCE FILMS HAVING ACRYLAMIDE LAYER AND METHOD OF MAKING SAME 3M INNOVATIVE PROPERTIES COMPANY (US) 2008-07-10 WO claimed
US-20080160185-A1 INTERFERENCE FILMS HAVING ACRYLAMIDE LAYER AND METHOD OF MAKING SAME 3M INNOVATIVE PROPERTIES COMPANY 2008-07-03 US claimed
US-20250188073-A1 TRICYCLIC COMPOUNDS AS INHIBITORS OF KRAS INCYTE CORP (US) 2025-06-12 US disclosed
EP-4548918-A2 TRICYCLIC COMPOUNDS AS INHIBITORS OF KRAS Incyte Corporation (US) 2025-05-07 EP disclosed
CN-111448190-B Substituted indole compounds 百时美施贵宝公司 2023-09-26 CN disclosed
WO-2023133943-A1 CROSS-LINKED POLYAMIC ACID ESTER AND PREPARATION METHOD THEREFOR, POLYIMIDE COMPOSITION COMPRISING SAME, AND METHOD FOR PREPARING POLYIMIDE RESIN FILM 深圳职业技术学院 2023-07-20 WO disclosed
CN-109843858-B Certain chemical entities, compositions and methods 润新生物公司 2023-05-05 CN disclosed
EP-4135844-A1 FUSED TRICYCLIC KRAS INHIBITORS Incyte Corporation (US) 2023-02-22 EP disclosed
CN-115702025-A Fused tricyclic KRAS inhibitors 因赛特公司 2023-02-14 CN disclosed
US-6608203-B2 Devoid of unwanted side effects PFIZER INC. 2003-08-19 US disclosed
US-20030134836-A1 Substituted arylamine derivatives and methods of use AMGEN INC. 2003-07-17 US disclosed
US-20030125339-A1 Substituted alkylamine derivatives and methods of use AMGEN INC. 2003-07-03 US disclosed
WO-2002068406-A2 SUBSTITUTED AMINE DERIVATIVES AND THEIR USE FOR THE TREATMENT OF ANGIOGENESIS AMGEN INC. (US) 2002-09-06 WO disclosed
WO-2002066470-A1 SUBSTITUTED ALKYLAMINE DERIVATIVES AND METHODS OF USE AMGEN INC. (US) 2002-08-29 WO disclosed
US-20010039285-A1 Tetrahydroisoquinoline compounds as estrogen agonists/antagonists CAMERON KIMBERLY O (US) 2001-11-08 US disclosed
EP-1113007-A1 Tetrahydroisoquinoline compounds as estrogen agonists/antagonists PFIZER INC. (US) 2001-07-04 EP disclosed
US-4239901-A ANALGESICS, ANTIPYRETICS, ANTIINFLAMMATORY AGENTS BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1980-12-16 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010039285-A1 Tetrahydroisoquinoline compounds as estrogen agonists/antagonists GPER1, ESR1, ESR2 HSD17B10 721/4885SMN1; SMN2 3840/4885
US-20030125339-A1 Substituted alkylamine derivatives and methods of use AADAC, NAT1, PIGO HSD17B10 1253/4885SMN1; SMN2 2090/4885
US-20030134836-A1 Substituted arylamine derivatives and methods of use NAT1, AADAC, AHR HSD17B10 1351/4885SMN1; SMN2 2424/4885
US-20250188073-A1 TRICYCLIC COMPOUNDS AS INHIBITORS OF KRAS KRAS, NRAS, HRAS HSD17B10 2884/4885SMN1; SMN2 3775/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.