Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 9/20 | 0.59 |
| ▸ | OPRD1 | P41143 | 9/20 | 0.59 |
| ▸ | OPRK1 | P41145 | 9/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | MAOB | P27338 | 1/20 | 0.38 |
| ▸ | FYN | P06241 | 1/20 | 0.38 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.36 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.35 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.35 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.35 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4478715 | 0.92 | OPRM1 (0.64) | OPRM1OPRD1OPRK1HDAC1KDM1A | |
| SCHEMBL4485653 | 0.85 | OPRM1 (0.57) | OPRM1OPRD1OPRK1HDAC1KDM1A | |
| SCHEMBL12651157 | 0.84 | OPRM1 (0.58) | OPRM1OPRD1OPRK1HDAC1KDM1A | |
| SCHEMBL4084233 | 0.84 | OPRM1 (0.57) | OPRM1OPRD1OPRK1HDAC1KDM1A | |
| SCHEMBL12607941 | 0.82 | OPRM1 (0.55) | OPRM1OPRD1OPRK1HDAC1KDM1A | |
| Hydrochloric Acid SCHEMBL3337917 | 0.81 | OPRM1 (0.55) | OPRM1OPRD1OPRK1HDAC1KDM1A | |
| SCHEMBL4081847 | 0.80 | OPRM1 (0.54) | OPRM1OPRD1OPRK1HDAC1KDM1A | |
| SCHEMBL4071959 | 0.80 | OPRM1 (0.53) | OPRM1OPRD1OPRK1HDAC1KDM1A | |
| SCHEMBL4392907 | 0.79 | OPRM1 (0.54) | OPRM1OPRD1OPRK1HDAC1KDM1A | |
| Trifluoroacetic Acid SCHEMBL3339975 | 0.79 | OPRM1 (0.52) | OPRM1OPRD1OPRK1HDAC1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7615651-B2 | Diaryl, dipyridinyl and aryl-pyridinyl derivatives and uses thereof | PFIZER INC. (US) | 2009-11-10 | — | — | US | claimed |