SCHEMBL448758

SCHEMBL448758

C1=Cc2ccccc2NCC1

nearest known ligand 0.44

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
GAA P10253 3/20 0.44
MAPT P10636 2/20 0.44
MEN1 O00255 2/20 0.35
KMT2A Q03164 2/20 0.35
ALDH1A1 P00352 1/20 0.35
KDM4E B2RXH2 1/20 0.31
NPC1 O15118 1/20 0.31
RXFP1 Q9HBX9 1/20 0.31
KDM1A O60341 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28264866 0.98 GAA (0.43) GAAMAPTMEN1KMT2AALDH1A1
SCHEMBL28986081 0.98 GAA (0.43) GAAMAPTMEN1KMT2AALDH1A1
SCHEMBL12471147 0.88 GAA (0.41) GAAMAPTMEN1KMT2AALDH1A1
SCHEMBL3041192 0.88 GAA (0.41) GAAMAPTMEN1KMT2AALDH1A1
SCHEMBL28173102 0.88 GAA (0.35) GAAMAPT
SCHEMBL11611273 0.84 GAA (0.39) GAAMAPT
SCHEMBL11611264 0.84 GAA (0.39) GAAMAPT
SCHEMBL28596071 0.83 MAPT (0.36) GAAMAPTMEN1KMT2AALDH1A1
Benzodiazepine SCHEMBL28173103 0.82 GAA (0.32) GAAMAPT
SCHEMBL29415525 0.77 GAA (0.48) GAAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 577 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-122071492-A Organic electroluminescent material and device 环球展览公司 2026-05-22 CN claimed
CN-122071494-A Organic electroluminescent material and device 环球展览公司 2026-05-22 CN claimed
CN-112236434-B Polycyclic compound and organic light emitting device including the same 株式会社LG化学 2024-02-23 CN claimed
US-20240052256-A1 BENZAZEPINE COMPOUNDS AS ANTIOXIDANTS FOR LUBRICANT COMPOSITIONS THE LUBRIZOL CORPORATION 2024-02-15 US claimed
EP-4267707-A1 BENZAZEPINE COMPOUNDS AS ANTIOXIDANTS FOR LUBRICANT COMPOSITIONS The Lubrizol Corporation (US) 2023-11-01 EP claimed
CN-116685663-A Benzazepine compounds as antioxidants for lubricating compositions 路博润公司 2023-09-01 CN claimed
WO-2022140496-A1 BENZAZEPINE COMPOUNDS AS ANTIOXIDANTS FOR LUBRICANT COMPOSITIONS THE LUBRIZOL CORPORATION (US) 2022-06-30 WO claimed
CN-113861128-A Polymerizable compound and optically anisotropic body 江苏创拓新材料有限公司 2021-12-31 CN claimed
CN-103214431-A 2,3-dihydrobenzazapine*compound or its salt and its medical application UNIV FUDAN 2013-07-24 CN claimed
EP-1852420-B1 Indole compounds for treating respiratory disorders ONO PHARMACEUTICAL CO (JP) 2012-10-17 EP claimed
US-8153625-B2 Nitrogen-containing heterocyclic compounds and medicinal use thereof ONO PHARMACEUTICAL CO., LTD. (JP) 2012-04-10 US claimed
US-7759336-B2 Nitrogen-containing heterocyclic compounds and medicinal use thereof ONO PHARMACEUTICAL CO., LTD. (JP) 2010-07-20 US claimed
US-20030018056-A1 Substituted guanidine derivatives SUMITOMO PHARMACEUTICALS COMPANY LIMITED (JP) 2003-01-23 US claimed
EP-1238971-A1 SUBSTITUTED GUANIDINE DERIVATIVES SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 2002-09-11 EP claimed
US-5753677-A Benzoheterocyclic compounds OTSUKA PHARMACEUTICAL CO., LTD. (JP) 1998-05-19 US claimed
EP-0450097-B1 BENZOHETEROCYCLIC COMPOUNDS OTSUKA PHARMA CO LTD (JP) 1996-04-24 EP claimed
JP-8059624-A None JP disclosed
CN-122071494-A Organic electroluminescent material and device 环球展览公司 2026-05-22 CN disclosed
US-4265890-A ANTIPSYCHOTIC, ANTIEMETICS SMITHKLINE CORPORATION (US) 1981-05-05 US disclosed
EP-0007070-A1 2,3,4,5-Tetrahydro-1H-3-Benzazepines, process for their production and pharmaceutical compositions having dopamine receptor blocking activity SMITHKLINE BECKMAN CORPORATION (US) 1980-01-23 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030018056-A1 Substituted guanidine derivatives SLC28A1, SLC7A1, ABCB11 GAA 292/4885MAPT 4395/4885MEN1 2803/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.