⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL578470 | 0.78 | — | — | |
| SCHEMBL15211144 | 0.75 | — | — | |
| SCHEMBL9723039 | 0.73 | — | — | |
| SCHEMBL331880 | 0.73 | — | — | |
| SCHEMBL23062 | 0.73 | — | — | |
| SCHEMBL1230818 | 0.73 | — | — | |
| SCHEMBL22024393 | 0.72 | — | — | |
| SCHEMBL5532955 | 0.72 | — | — | |
| SCHEMBL9868078 | 0.72 | — | — | |
| SCHEMBL140788 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024053650-A1 | COMPOUND HAVING INHIBITORY ACTIVITY AGAINST DIACYLGLYCEROL KINASE α AND/OR ζ, AND PHARMACEUTICAL USE THEREOF | 小野薬品工業株式会社 | 2024-03-14 | — | — | WO | disclosed |
| US-20230014137-A1 | COMPOUND HAVING LYSOPHOSPHATIDIC ACID RECEPTOR AGONIST ACTIVITY AND PHARMACEUTICAL USE THEREOF | ONO PHARMACEUTICAL CO., LTD. (JP) | 2023-01-19 | — | — | US | disclosed |
| WO-2021107125-A1 | COMPOUND HAVING LYSOPHOSPHATIDIC ACID RECEPTOR AGONISTIC ACTIVITY AND PHARMACEUTICAL USE OF SAID COMPOUND | 小野薬品工業株式会社 | 2021-06-03 | — | — | WO | disclosed |
| CN-101012211-B | Substituted andrographolide derivative, preparing method and pharmaceutical compound thereof | UNIV CHINA PHARMA | 2010-12-15 | — | — | CN | disclosed |
| US-7494987-B2 | Agent for treating respiratory diseases containing 4-hydroxypiperidine derivative as active ingredient | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2009-02-24 | — | — | US | disclosed |
| CN-101028263-A | Use of substituted isoandrographolide derivative | CHINA PHARMACEUTICS UNIV (CN) | 2007-09-05 | — | — | CN | disclosed |
| CN-101028260-A | Use of substitutive isoandrographolide derivative | CHINA PHARMACEUTICS UNIV (CN) | 2007-09-05 | — | — | CN | disclosed |
| CN-101029046-A | Substituted isoandrographolide derivative, its production and medicinal composition | CHINA PHARMACEUTICS UNIV (CN) | 2007-09-05 | — | — | CN | disclosed |
| CN-101012211-A | Substituted andrographolide derivative, preparing method and pharmaceutical compound thereof | UNIV CHINA PHARMA (CN) | 2007-08-08 | — | — | CN | disclosed |
| US-20060040985-A1 | Therapeutic agent for treating respiratory diseases containing 4-hydroxypiperidine derivative as active ingredient | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2006-02-23 | — | — | US | disclosed |
| EP-1568688-A1 | THERAPEUTIC AGENT FOR RESPIRATORY DISEASE CONTAINING 4-HYDROXYPIPERIDINE DERIVATIVE AS ACTIVE INGREDIENT | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2005-08-31 | — | — | EP | disclosed |