Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 12/20 | 0.59 |
| ▸ | FGFR2 | P21802 | 5/20 | 0.53 |
| ▸ | FGFR3 | P22607 | 5/20 | 0.53 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.52 |
| ▸ | FGFR4 | P22455 | 3/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.49 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.49 |
| ▸ | PAK4 | O96013 | 1/20 | 0.49 |
| ▸ | CDK2 | P24941 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.49 |
| ▸ | CLK2 | P49760 | 1/20 | 0.49 |
| ▸ | CDK7 | P50613 | 1/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.49 |
| ▸ | PRKX | P51817 | 1/20 | 0.49 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.49 |
| ▸ | MELK | Q14680 | 1/20 | 0.49 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4490432 | 0.92 | HDAC6 (0.60) | HDAC6FGFR2FGFR3FGFR1GSK3B | |
| SCHEMBL4493689 | 0.87 | HDAC6 (0.62) | HDAC6FGFR2FGFR3FGFR1GSK3B | |
| SCHEMBL4492281 | 0.86 | HDAC6 (0.63) | HDAC6FGFR2FGFR3FGFR1FGFR4 | |
| SCHEMBL4486529 | 0.86 | FGFR2 (0.51) | HDAC6FGFR2FGFR3FGFR1GSK3B | |
| SCHEMBL4494342 | 0.86 | HDAC6 (0.55) | HDAC6FGFR2FGFR3FGFR1GSK3B | |
| SCHEMBL4486923 | 0.85 | HDAC6 (0.73) | HDAC6FGFR2FGFR3FGFR1GSK3B | |
| SCHEMBL4503166 | 0.82 | HDAC6 (0.60) | HDAC6FGFR2FGFR3FGFR1GSK3B | |
| SCHEMBL4491840 | 0.82 | FGFR2 (0.62) | HDAC6FGFR2FGFR3FGFR1GSK3B | |
| SCHEMBL4488594 | 0.82 | HDAC6 (0.60) | HDAC6FGFR2FGFR3FGFR1FGFR4 | |
| SCHEMBL4486938 | 0.81 | HDAC6 (0.64) | HDAC6FGFR2FGFR3FGFR1GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |