SCHEMBL4489612

SCHEMBL4489612

CC(C(=O)O)c1ccccc1Cn1ccc(OCc2ccc(F)cc2F)c(Br)c1=O

nearest known ligand 0.62

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
MAPK14 Q16539 20/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4378508 0.86 MAPK14 (0.67) MAPK14
SCHEMBL4473838 0.84 MAPK14 (0.75) MAPK14
SCHEMBL27602814 0.84 MAPK14 (0.64) MAPK14
SCHEMBL4376205 0.83 MAPK14 (0.66) MAPK14
SCHEMBL4374069 0.83 MAPK14 (0.71) MAPK14
SCHEMBL4392621 0.82 MAPK14 (0.79) MAPK14
SCHEMBL4384770 0.80 MAPK14 (0.73) MAPK14
SCHEMBL4384403 0.79 MAPK14 (0.70) MAPK14
SCHEMBL4375930 0.78 MAPK14 (0.73) MAPK14
SCHEMBL4473632 0.78 MAPK14 (0.71) MAPK14

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7629363-B2 antiinflammatory agent for treating asthma and chronic pulmonary inflammatory disease PFIZER INC (US) 2009-12-08 US disclosed