Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 3/20 | 0.61 |
| ▸ | SIK1 | P57059 | 2/20 | 0.61 |
| ▸ | SIK2 | Q9H0K1 | 2/20 | 0.61 |
| ▸ | SIK3 | Q9Y2K2 | 2/20 | 0.61 |
| ▸ | FLT3 | P36888 | 4/20 | 0.57 |
| ▸ | BTK | Q06187 | 2/20 | 0.57 |
| ▸ | SYK | P43405 | 2/20 | 0.57 |
| ▸ | BRD4 | O60885 | 6/20 | 0.56 |
| ▸ | JAK1 | P23458 | 3/20 | 0.56 |
| ▸ | JAK3 | P52333 | 4/20 | 0.55 |
| ▸ | BRDT | Q58F21 | 2/20 | 0.55 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 3/20 | 0.52 |
| ▸ | PAK1 | Q13153 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.52 |
| ▸ | CDK2 | P24941 | 2/20 | 0.52 |
| ▸ | CDC7 | O00311 | 1/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4499216 | 0.88 | SIK1 (0.53) | AXLSIK1SIK2SIK3FLT3 | |
| SCHEMBL4504802 | 0.88 | PKMYT1 (0.62) | FLT3SLC2A1PAK1KDRMAPK9 | |
| SCHEMBL4489927 | 0.85 | CDK4 (0.66) | SYKBRD4SLC2A1CDK2AURKA | |
| SCHEMBL4496506 | 0.82 | SRC (0.53) | SIK1SIK2SIK3FLT3BTK | |
| SCHEMBL5686213 | 0.80 | FLT3 (0.58) | AXLSIK1SIK2SIK3FLT3 | |
| SCHEMBL4486375 | 0.78 | SIK1 (0.63) | AXLSIK1SIK2SIK3FLT3 | |
| SCHEMBL4496398 | 0.77 | TNK2 (0.54) | AXLBTKJAK1JAK3JAK2 | |
| SCHEMBL4484592 | 0.77 | SIK1 (0.66) | AXLSIK1SIK2SIK3FLT3 | |
| SCHEMBL29076259 | 0.77 | SIK1 (0.95) | AXLSIK1SIK2SIK3FLT3 | |
| SCHEMBL31612075 | 0.77 | SIK1 (0.95) | AXLSIK1SIK2SIK3FLT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7504396-B2 | Substituted heterocyclic compounds and methods of use | AMGEN INC. (US) | 2009-03-17 | — | — | US | disclosed |
| US-20050209221-A1 | Substituted heterocyclic compounds and methods of use | AMGEN INC. | 2005-09-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050209221-A1 | Substituted heterocyclic compounds and methods of use | ICOS, CD4, HLA-DRB1 | AXL 2557/4885SIK1 1588/4885SIK2 1559/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.