Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.49 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.39 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.39 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | TYMS | P04818 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.37 |
| ▸ | PRKDC | P78527 | 1/20 | 0.37 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.37 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | CA7 | P43166 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA4 | P22748 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4561729 | 0.86 | PIK3CA (0.48) | PIK3CDPIK3CAPIK3CGPIK3CBDHFR | |
| SCHEMBL4635464 | 0.79 | PIK3CA (0.48) | PIK3CDPIK3CAPIK3CGPIK3CBDHFR | |
| SCHEMBL4635562 | 0.76 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CGPIK3CBDHFR | |
| SCHEMBL189523 | 0.76 | PIK3CD (0.70) | PIK3CDPIK3CAPIK3CGPIK3CBMEN1 | |
| SCHEMBL4341736 | 0.74 | TYMS (0.52) | PIK3CDPIK3CAPIK3CGPIK3CBDHFR | |
| SCHEMBL4516048 | 0.73 | PIK3CD (0.48) | PIK3CDPIK3CAPIK3CGPIK3CBDHFR | |
| SCHEMBL4636003 | 0.73 | PIK3CA (0.56) | PIK3CDPIK3CAPIK3CGPIK3CBDHFR | |
| SCHEMBL27901625 | 0.71 | PIK3CA (0.53) | PIK3CDPIK3CAPIK3CGPIK3CBDHFR | |
| SCHEMBL4466147 | 0.71 | PIK3CA (0.50) | PIK3CDPIK3CAPIK3CGPIK3CBDHFR | |
| SCHEMBL4519093 | 0.71 | PIK3CG (0.55) | PIK3CDPIK3CAPIK3CGPIK3CBDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2056829-A2 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | Exelixis, Inc. (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008021389-A2 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | EXELIXIS, INC. (US) | 2008-02-21 | — | — | WO | disclosed |