Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 4/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.46 |
| ▸ | PIK3CG | P48736 | 9/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.43 |
| ▸ | TYMS | P04818 | 2/20 | 0.40 |
| ▸ | DHFR | P00374 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.36 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.36 |
| ▸ | MELK | Q14680 | 2/20 | 0.36 |
| ▸ | MTOR | P42345 | 1/20 | 0.36 |
| ▸ | PRKDC | P78527 | 1/20 | 0.36 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.36 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | TNF | P01375 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4635562 | 0.85 | PIK3CD (0.47) | PIK3CDPIK3CAPIK3CGPIK3CBTYMS | |
| SCHEMBL4466147 | 0.83 | PIK3CA (0.50) | PIK3CDPIK3CAPIK3CGPIK3CBTYMS | |
| SCHEMBL4847541 | 0.81 | PIK3CA (0.52) | PIK3CDPIK3CAPIK3CGPIK3CBTYMS | |
| SCHEMBL27901625 | 0.80 | PIK3CA (0.53) | PIK3CDPIK3CAPIK3CGPIK3CBTYMS | |
| SCHEMBL188760 | 0.77 | PIK3CD (0.67) | PIK3CDPIK3CAPIK3CGPIK3CBMAPT | |
| SCHEMBL4636003 | 0.77 | PIK3CA (0.56) | PIK3CDPIK3CAPIK3CGPIK3CBTYMS | |
| SCHEMBL14306601 | 0.74 | PIK3CD (0.59) | PIK3CDPIK3CAPIK3CGPIK3CBMAPT | |
| SCHEMBL4489850 | 0.73 | PIK3CD (0.49) | PIK3CDPIK3CAPIK3CGPIK3CBTYMS | |
| SCHEMBL27901724 | 0.72 | PIK3CA (0.58) | PIK3CDPIK3CAPIK3CGPIK3CBTYMS | |
| SCHEMBL4539741 | 0.72 | PIK3CA (0.48) | PIK3CDPIK3CAPIK3CGPIK3CBTYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2056829-A2 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | Exelixis, Inc. (US) | 2009-05-13 | — | — | EP | disclosed |
| WO-2008021389-A2 | USING PI3K AND MEK MODULATORS IN TREATMENTS OF CANCER | EXELIXIS, INC. (US) | 2008-02-21 | — | — | WO | disclosed |