Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 13/20 | 0.66 |
| ▸ | GSK3A | P49840 | 4/20 | 0.66 |
| ▸ | CDK2 | P24941 | 3/20 | 0.66 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.64 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.57 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.45 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.45 |
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4503167 | 0.93 | GSK3B (0.64) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4497268 | 0.92 | GSK3B (0.68) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4495093 | 0.91 | GSK3B (0.67) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4495422 | 0.90 | GSK3B (0.66) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4482867 | 0.89 | GSK3B (0.68) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4492221 | 0.88 | GSK3B (0.69) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4487663 | 0.86 | GSK3B (0.58) | GSK3BGSK3ACDK2AAK1PIK3CD | |
| SCHEMBL4476075 | 0.84 | GSK3B (0.63) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4489355 | 0.83 | HDAC6 (0.60) | GSK3BGSK3ACDK2HDAC1HDAC2 | |
| SCHEMBL4498065 | 0.83 | AAK1 (0.50) | GSK3BGSK3AHDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |