Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 12/20 | 0.67 |
| ▸ | GSK3A | P49840 | 8/20 | 0.67 |
| ▸ | CDK2 | P24941 | 4/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.58 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.58 |
| ▸ | AAK1 | Q2M2I8 | 6/20 | 0.46 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.46 |
| ▸ | PIM1 | P11309 | 1/20 | 0.46 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.43 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4497268 | 0.99 | GSK3B (0.68) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4489993 | 0.91 | GSK3B (0.66) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4495422 | 0.91 | GSK3B (0.66) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4503167 | 0.90 | GSK3B (0.64) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4492221 | 0.89 | GSK3B (0.69) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4482867 | 0.88 | GSK3B (0.68) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4476075 | 0.86 | GSK3B (0.63) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4491371 | 0.84 | GSK3B (0.59) | GSK3BGSK3ACDK2AAK1PIK3CD | |
| SCHEMBL4479967 | 0.82 | GSK3B (0.60) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4488341 | 0.82 | GSK3B (0.60) | GSK3BGSK3ACDK2AAK1PIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |
| EP-1506176-B1 | AMINOINDAZOLE DERIVATIVES ACTIVE AS KINASE INHIBITORS, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM | PFIZER ITALIA SRL (IT) | 2013-04-24 | — | — | EP | disclosed |
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | disclosed |
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | disclosed |