Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 12/20 | 0.58 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | BCR | P11274 | 1/20 | 0.53 |
| ▸ | AAK1 | Q2M2I8 | 4/20 | 0.50 |
| ▸ | GSK3A | P49840 | 2/20 | 0.50 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.50 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | CDK2 | P24941 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4488341 | 0.91 | GSK3B (0.60) | GSK3BABL1BCRAAK1GSK3A | |
| SCHEMBL4498271 | 0.90 | AAK1 (0.50) | GSK3BAAK1GSK3AHDAC6 | |
| SCHEMBL4491371 | 0.90 | GSK3B (0.59) | GSK3BABL1BCRAAK1GSK3A | |
| SCHEMBL4487663 | 0.89 | GSK3B (0.58) | GSK3BABL1BCRAAK1GSK3A | |
| SCHEMBL4559025 | 0.89 | GSK3B (0.58) | GSK3BABL1BCRAAK1GSK3A | |
| SCHEMBL4497972 | 0.87 | GSK3B (0.56) | GSK3BABL1BCRAAK1GSK3A | |
| SCHEMBL4491947 | 0.87 | GSK3B (0.56) | GSK3BABL1BCRAAK1GSK3A | |
| SCHEMBL4495422 | 0.84 | GSK3B (0.66) | GSK3BAAK1GSK3APIK3CDPIM1 | |
| SCHEMBL4490316 | 0.83 | HDAC1 (0.63) | GSK3BGSK3AHDAC6FGFR1FGFR2 | |
| SCHEMBL4502580 | 0.81 | GSK3B (0.52) | GSK3BAAK1GSK3AHDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |