Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 8/20 | 0.50 |
| ▸ | GSK3B | P49841 | 6/20 | 0.50 |
| ▸ | GSK3A | P49840 | 3/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4502580 | 0.92 | GSK3B (0.52) | AAK1GSK3BGSK3AHDAC6HDAC1 | |
| SCHEMBL4500019 | 0.91 | RAB9A (0.52) | AAK1GSK3BGSK3AHDAC6HDAC1 | |
| SCHEMBL4490606 | 0.90 | GSK3B (0.58) | AAK1GSK3BGSK3AHDAC6 | |
| SCHEMBL4503789 | 0.90 | AAK1 (0.52) | AAK1GSK3BGSK3AHDAC6HDAC1 | |
| SCHEMBL4498065 | 0.90 | AAK1 (0.50) | AAK1GSK3BGSK3AHDAC6HDAC1 | |
| SCHEMBL4492106 | 0.88 | GSK3B (0.53) | AAK1GSK3BGSK3AHDAC6HDAC1 | |
| SCHEMBL4491206 | 0.88 | AAK1 (0.54) | AAK1GSK3BGSK3AHDAC6HDAC1 | |
| SCHEMBL4490316 | 0.87 | HDAC1 (0.63) | GSK3BGSK3AHDAC6HDAC1HDAC2 | |
| SCHEMBL12886054 | 0.84 | MAPT (0.48) | AAK1GSK3BGSK3AHDAC6 | |
| SCHEMBL12886065 | 0.81 | DPP4 (0.46) | AAK1GSK3BGSK3AHDAC6HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |