Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.71 |
| ▸ | GSK3B | P49841 | 4/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.53 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.53 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.53 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.49 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.48 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4488789 | 0.89 | HDAC6 (0.56) | HDAC6HDAC1HDAC2HDAC8FGFR4 | |
| SCHEMBL4488293 | 0.89 | HDAC6 (0.75) | HDAC6GSK3BHDAC1HDAC2HDAC8 | |
| SCHEMBL4485209 | 0.89 | HDAC6 (0.70) | HDAC6GSK3BHDAC1HDAC2HDAC8 | |
| SCHEMBL4499137 | 0.88 | HDAC6 (0.55) | HDAC6GSK3BHDAC1HDAC2HDAC8 | |
| SCHEMBL4492160 | 0.88 | HDAC6 (0.66) | HDAC6GSK3BHDAC1HDAC2HDAC8 | |
| SCHEMBL4481457 | 0.87 | GSK3B (0.69) | HDAC6GSK3BHDAC1HDAC2HDAC8 | |
| SCHEMBL4503997 | 0.87 | HDAC6 (0.63) | HDAC6GSK3BHDAC1HDAC2HDAC8 | |
| SCHEMBL4499922 | 0.86 | HDAC6 (0.71) | HDAC6GSK3BHDAC1HDAC2HDAC8 | |
| SCHEMBL12886049 | 0.85 | HDAC6 (0.66) | HDAC6GSK3BHDAC1HDAC2HDAC8 | |
| SCHEMBL4494613 | 0.85 | GSK3B (0.57) | HDAC6GSK3BHDAC1HDAC2HDAC8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |