Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 7/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 5/20 | 0.52 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.49 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.49 |
| ▸ | GSK3A | P49840 | 1/20 | 0.49 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4481457 | 0.91 | GSK3B (0.69) | GSK3BHDAC6AAK1CYP1A2HDAC1 | |
| SCHEMBL4491636 | 0.87 | GSK3B (0.60) | GSK3BHDAC6AAK1CYP1A2HDAC1 | |
| SCHEMBL4491027 | 0.87 | GSK3B (0.69) | GSK3BAAK1CYP1A2GSK3ADYRK1A | |
| SCHEMBL4505048 | 0.85 | GSK3B (0.49) | GSK3BHDAC6CYP1A2HDAC1HDAC2 | |
| SCHEMBL4490810 | 0.85 | HDAC6 (0.71) | GSK3BHDAC6AAK1CYP1A2HDAC1 | |
| SCHEMBL4497666 | 0.84 | GSK3B (0.69) | GSK3BHDAC6AAK1CYP1A2GSK3A | |
| SCHEMBL4502564 | 0.83 | GSK3B (0.60) | GSK3BHDAC6CYP1A2HDAC1HDAC2 | |
| SCHEMBL4503496 | 0.82 | GSK3B (0.48) | GSK3BHDAC6CYP1A2HDAC1HDAC2 | |
| SCHEMBL4488620 | 0.81 | HDAC6 (0.61) | GSK3BHDAC6CYP1A2HDAC1HDAC2 | |
| SCHEMBL4488994 | 0.81 | HDAC6 (0.70) | GSK3BHDAC6AAK1HDAC1HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |