Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.62 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.59 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.59 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 5/20 | 0.48 |
| ▸ | GSK3A | P49840 | 3/20 | 0.48 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.44 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIM1 | P11309 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4493488 | 0.93 | HDAC6 (0.62) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL4494040 | 0.91 | HDAC6 (0.65) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL12886226 | 0.90 | HDAC6 (0.63) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL4491630 | 0.90 | HDAC6 (0.63) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL4489154 | 0.90 | HDAC6 (0.63) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL12886066 | 0.85 | HDAC6 (0.58) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL4487348 | 0.85 | HDAC6 (0.58) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL4476288 | 0.85 | HDAC1 (0.66) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL12886069 | 0.83 | GSK3B (0.59) | GSK3BGSK3AAAK1PIK3CDPIM1 | |
| SCHEMBL4493050 | 0.82 | GSK3B (0.72) | HDAC6HDAC1HDAC2HDAC8GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |