Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.63 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.60 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.60 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.60 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.51 |
| ▸ | FGFR2 | P21802 | 3/20 | 0.51 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.49 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 2/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.45 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4494040 | 0.92 | HDAC6 (0.65) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL4491630 | 0.90 | HDAC6 (0.63) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL12886226 | 0.90 | HDAC6 (0.63) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL4491284 | 0.90 | HDAC6 (0.62) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL4493488 | 0.90 | HDAC6 (0.62) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL12886066 | 0.86 | HDAC6 (0.58) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL4490316 | 0.83 | HDAC1 (0.63) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL4494484 | 0.82 | HDAC6 (0.74) | HDAC6HDAC1HDAC2HDAC8FGFR1 | |
| SCHEMBL4493050 | 0.81 | GSK3B (0.72) | HDAC6HDAC1HDAC2HDAC8GSK3B | |
| SCHEMBL4490606 | 0.81 | GSK3B (0.58) | HDAC6FGFR1FGFR2GSK3BGSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |