Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 19/20 | 0.68 |
| ▸ | HRH2 | P25021 | 15/20 | 0.68 |
| ▸ | HRH1 | P35367 | 15/20 | 0.68 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14150224 | 1.00 | HRH3 (0.68) | HRH3HRH2HRH1MEN1 | |
| SCHEMBL4494406 | 0.97 | HRH3 (0.68) | HRH3HRH2HRH1MEN1 | |
| SCHEMBL4684886 | 0.96 | HRH3 (0.66) | HRH3HRH2HRH1MEN1 | |
| SCHEMBL1978291 | 0.94 | HRH3 (0.71) | HRH3HRH2HRH1 | |
| SCHEMBL4622791 | 0.93 | HRH3 (0.59) | HRH3HRH2HRH1MEN1 | |
| Oxalic Acid SCHEMBL4500933 | 0.92 | HRH3 (0.65) | HRH3HRH2HRH1MEN1 | |
| Oxalic Acid SCHEMBL4495484 | 0.90 | HRH3 (0.61) | HRH3HRH2HRH1MEN1 | |
| SCHEMBL4622889 | 0.89 | HRH3 (0.65) | HRH3HRH2HRH1MEN1 | |
| Oxalic Acid SCHEMBL4493442 | 0.89 | HRH3 (0.60) | HRH3HRH2HRH1MEN1 | |
| SCHEMBL3828011 | 0.88 | HRH3 (0.71) | HRH3HRH2HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7576120-B2 | Azabicyclic compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2009-08-18 | — | — | US | claimed |
| EP-1720544-B1 | NOVEL AZABICYCLIC DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2008-03-19 | — | — | EP | claimed |
| US-20070197625-A1 | Azabicyclic compounds, a process for their preparation and pharmaceutical compositions containing them. | LES LABORATORATIES SERVIER (FR) | 2007-08-23 | — | — | US | claimed |
| EP-2532651-B1 | Synthesis process, and crystalline form of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1h)-yl]propoxy}benzamide hydrochloride and its free base as well as the pharmaceutical compositions containing them | SERVIER LAB (FR) | 2015-08-05 | — | — | EP | disclosed |
| US-8952179-B2 | Synthesis process, and crystalline form of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]propoxy} benzamide hydrochloride and pharmaceutical compositions containing it | LES LABORATORIES SERVIER (FR) | 2015-02-10 | — | — | US | disclosed |
| US-20140155453-A1 | SYNTHESIS PROCESS, AND CRYSTALLINE FORM OF 4-{3[CIS-HEXAHYDROCYCLOPENT A[CjPYRROL-2( 1 H)-YLjPROPOXYj BENZAMI DE HYDROCHLORI DE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT | LES LABORATOIRES SERVIER (FR) | 2014-06-05 | — | — | US | disclosed |
| US-20140100374-A1 | SYNTHESIS PROCESS, AND CRYSTALLINE FORM OF 4- BENZAMIDE HYDROCHLORIDE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT | LES LABORATOIRES SERVIER (FR) | 2014-04-10 | — | — | US | disclosed |
| US-8664408-B2 | Synthesis process, and crystalline form of 4-{3-[cis-hexahydrocyclopenta[c]pyrrol-2(1H)-yl]proxy}benzamide hydrochloride and pharmaceutical compositions containing it | LES LABORATOIRES SERVIER (FR) | 2014-03-04 | — | — | US | disclosed |
| WO-2012168657-A1 | PROCESS FOR SYNTHESIS AND CRYSTALLINE FORM OF 4-{3-[CIS-HEXAHYDROCYCLOPENTA[C]PYRROL-2(1H)-YL]PROPOXY}BENZAMIDE HYDROCHLORIDE, IN ADDITION TO THE ASSOCIATED FREE BASE AND THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2012-12-13 | — | — | WO | disclosed |
| US-20120316214-A1 | SYNTHESIS PROCESS, AND CRYSTALLINE FORM OF 4-BENZAMIDE HYDROCHLORIDE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT | LES LABORATOIRES SERVIER (FR) | 2012-12-13 | — | — | US | disclosed |
| US-7576120-B2 | Azabicyclic compounds, a process for their preparation and pharmaceutical compositions containing them | LES LABORATOIRES SERVIER (FR) | 2009-08-18 | — | — | US | disclosed |
| EP-1720544-B1 | NOVEL AZABICYCLIC DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | SERVIER LAB (FR) | 2008-03-19 | — | — | EP | disclosed |
| US-20070197625-A1 | Azabicyclic compounds, a process for their preparation and pharmaceutical compositions containing them. | LES LABORATORATIES SERVIER (FR) | 2007-08-23 | — | — | US | disclosed |
| EP-1720544-A1 | NOVEL AZABICYCLIC DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | Les Laboratoires Servier (FR) | 2006-11-15 | — | — | EP | disclosed |
| WO-2005089747-A1 | NOVEL AZABICYCLIC DERIVATIVES, PREPARATION METHOD THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | LES LABORATOIRES SERVIER (FR) | 2005-09-29 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070197625-A1 | Azabicyclic compounds, a process for their preparation and pharmaceutical compositions containing them. | HRH2, HNMT, HRH1 | HRH3 9/4885HRH2 1/4885HRH1 3/4885 |
| US-20140155453-A1 | SYNTHESIS PROCESS, AND CRYSTALLINE FORM OF 4-{3[CIS-HEXAHYDROCYCLOPENT A[CjPYRROL-2( 1 H)-YLjPROPOXYj BENZAMI DE HYDROCHLORI DE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT | HRH2, HRH1, HRH4 | HRH3 6/4885HRH2 1/4885HRH1 2/4885 |
| US-20120316214-A1 | SYNTHESIS PROCESS, AND CRYSTALLINE FORM OF 4-BENZAMIDE HYDROCHLORIDE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT | HRH4, HRH2, HRH1 | HRH3 4/4885HRH2 2/4885HRH1 3/4885 |
| US-20140100374-A1 | SYNTHESIS PROCESS, AND CRYSTALLINE FORM OF 4- BENZAMIDE HYDROCHLORIDE AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT | CYP4B1, CYP3A4, CYP4F8 | HRH3 123/4885HRH2 41/4885HRH1 44/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.