Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324394 | 0.93 | TGFBR1 (0.88) | TGFBR1TGFBR2 | |
| Trifluoroacetic Acid SCHEMBL4477254 | 0.89 | TGFBR1 (0.65) | TGFBR1TGFBR2 | |
| SCHEMBL409714 | 0.87 | TGFBR1 (1.00) | TGFBR1TGFBR2 | |
| SCHEMBL8326198 | 0.85 | TGFBR1 (0.74) | TGFBR1TGFBR2 | |
| SCHEMBL8324430 | 0.84 | TGFBR1 (0.67) | TGFBR1TGFBR2 | |
| SCHEMBL412367 | 0.83 | TGFBR1 (0.94) | TGFBR1TGFBR2 | |
| Trifluoroacetic Acid SCHEMBL4475902 | 0.82 | TGFBR1 (0.62) | TGFBR1 | |
| SCHEMBL373822 | 0.82 | TGFBR1 (1.00) | TGFBR1TGFBR2 | |
| SCHEMBL4471671 | 0.81 | TGFBR1 (0.80) | TGFBR1 | |
| Trifluoroacetic Acid SCHEMBL4475893 | 0.81 | TGFBR1 (0.63) | TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7511065-B2 | Mixed lineage kinase modulators | ELI LILLY AND COMPANY (US) | 2009-03-31 | — | — | US | disclosed |
| US-20080113977-A1 | Mixed Lineage Kinase Modulators | ELI LILLY AND COMPANY | 2008-05-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080113977-A1 | Mixed Lineage Kinase Modulators | MYLK2, CSNK1G2, CSNK1A1 | TGFBR1 691/4885TGFBR2 562/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.