Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 4/20 | 0.39 |
| ▸ | BCR | P11274 | 4/20 | 0.39 |
| ▸ | BRAF | P15056 | 13/20 | 0.39 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13935897 | 0.91 | MAPK14 (0.40) | ABL1BCRBRAFMAPK11MAPK14 | |
| SCHEMBL13935937 | 0.91 | BRAF (0.49) | BRAFMAPK14 | |
| SCHEMBL4478482 | 0.89 | ABL1 (0.41) | ABL1BCRBRAFMAPK11MAPK14 | |
| SCHEMBL5178018 | 0.89 | MAPK14 (0.41) | ABL1BCRBRAFMAPK11MAPK14 | |
| SCHEMBL5179484 | 0.88 | ABL1 (0.38) | ABL1BCRBRAFMAPK11MAPK14 | |
| Pivalamide SCHEMBL5179479 | 0.85 | ABL1 (0.39) | ABL1BCRBRAFMAPK11MAPK14 | |
| SCHEMBL5175774 | 0.84 | BRAF (0.47) | ABL1BCRBRAF | |
| SCHEMBL5177283 | 0.84 | MAPK14 (0.41) | ABL1BCRBRAFMAPK11MAPK14 | |
| SCHEMBL4463798 | 0.83 | BRAF (0.40) | BRAF | |
| SCHEMBL5177015 | 0.83 | BRAF (0.49) | BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7485657-B2 | Anti-cytokine heterocyclic compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-02-03 | — | — | US | disclosed |
| US-7485657-B2 | Anti-cytokine heterocyclic compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-02-03 | — | — | US | disclosed |
| US-7485657-B2 | Anti-cytokine heterocyclic compounds | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2009-02-03 | — | — | US | disclosed |
| EP-1756065-A1 | ANTI-CYTOKINE HETEROCYCLIC COMPOUNDS | BOEHRINGER INGELHEIM PHARMACEUTICALS INC. (US) | 2007-02-28 | — | — | EP | disclosed |
| WO-2005115991-A1 | ANTI-CYTOKINE HETEROCYCLIC COMPOUNDS | BOEHRINGER INGELHEIM PHARMACEUTICALS, INC. (US) | 2005-12-08 | — | — | WO | disclosed |