Sugi Predict

Sugi Predict / Compounds / SCHEMBL4492407

SCHEMBL4492407

SCHEMBL4492407

O=C(O)CCCC=CC[C@H]1C(=O)CC[C@@H](O)[C@@H]1C=CC(O)CCc1sc2ccccc2c1Cl

nearest known ligand 0.73

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
▸ PTGER4 P35408 12/20 0.73
▸ PTGER3 P43115 6/20 0.52
▸ PTGFR P43088 5/20 0.52
▸ PTGER1 P34995 4/20 0.52
▸ PTGER2 P43116 2/20 0.52
▸ PTGIR P43119 2/20 0.52
▸ NR1I2 O75469 1/20 0.52
▸ ESR1 P03372 1/20 0.52
▸ PGR P06401 1/20 0.52
▸ HPGD P15428 1/20 0.52
▸ TSHR P16473 1/20 0.52
▸ TBXA2R P21731 1/20 0.52
▸ MAPK1 P28482 1/20 0.52
▸ OPRK1 P41145 1/20 0.52
▸ PDE4D Q08499 1/20 0.52
▸ MGLL Q99685 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4492402 1.00 PTGER4 (0.73) PTGER4PTGER3PTGFRPTGER1PTGER2
SCHEMBL129658 0.92 PTGER4 (0.75) PTGER4PTGER3PTGFRPTGER1PTGER2
SCHEMBL129656 0.92 PTGER4 (0.75) PTGER4PTGER3PTGFRPTGER1PTGER2
SCHEMBL129657 0.92 PTGER4 (0.75) PTGER4PTGER3PTGFRPTGER1PTGER2
SCHEMBL7131273 0.92 PTGER4 (0.75) PTGER4PTGER3PTGFRPTGER1PTGER2
SCHEMBL1011637 0.91 PTGER4 (0.68) PTGER4PTGER3PTGFRPTGER1PTGER2
SCHEMBL1013598 0.91 PTGER4 (0.68) PTGER4PTGER3PTGFRPTGER1PTGER2
SCHEMBL1011832 0.88 PTGER4 (0.73) PTGER4PTGER3PTGFRPTGER1PTGER2
SCHEMBL1010823 0.88 PTGER4 (0.73) PTGER4PTGER3PTGFRPTGER1PTGER2
SCHEMBL4502745 0.88 PTGER4 (0.67) PTGER4PTGER3PTGFRPTGER1PTGER2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-7015243-B2 Cyclohexyl prostaglandin analogs as EP4-receptor agonists ALLERGAN, INC. (US) 2006-03-21 — — US claimed
US-7473704-B2 Cyclohexyl prostaglandin analogs as EP4-receptor agonists ALLERGAN, INC. (US) 2009-01-06 — — US disclosed
US-7429615-B2 Cyclohexyl prostaglandin analogs as EP4-receptor agonists ALLERGAN, INC. (US) 2008-09-30 — — US disclosed
US-20060247215-A1 Cyclohexyl prostaglandin analogs as rp4-receptor agonists OLD DAVID W 2006-11-02 — — US disclosed
US-7015243-B2 Cyclohexyl prostaglandin analogs as EP4-receptor agonists ALLERGAN, INC. (US) 2006-03-21 — — US disclosed
US-20060030606-A1 Cyclohexyl prostaglandin analogs as EP4-receptor agonists ALLERGAN, INC. 2006-02-09 — — US disclosed
US-20050049227-A1 Cyclohexyl prostaglandin analogs as EP4-receptor agonists ALLERGAN, INC. 2005-03-03 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20060247215-A1 Cyclohexyl prostaglandin analogs as rp4-receptor agonists PTGER4, PTGER1, PTGER3 PTGER4 1/4885PTGER3 3/4885PTGFR 7/4885
US-20060030606-A1 Cyclohexyl prostaglandin analogs as EP4-receptor agonists PTGER4, PTGER1, PTGIR PTGER4 1/4885PTGER3 4/4885PTGFR 7/4885
US-20050049227-A1 Cyclohexyl prostaglandin analogs as EP4-receptor agonists PTGER4, PTGER1, PTGIR PTGER4 1/4885PTGER3 4/4885PTGFR 7/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.