Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 12/20 | 0.70 |
| ▸ | GSK3A | P49840 | 4/20 | 0.70 |
| ▸ | CDK2 | P24941 | 3/20 | 0.70 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.69 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.64 |
| ▸ | AAK1 | Q2M2I8 | 3/20 | 0.56 |
| ▸ | ACHE | P22303 | 3/20 | 0.51 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | PIM1 | P11309 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4491491 | 0.90 | GSK3B (0.73) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4491509 | 0.85 | GSK3B (0.91) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4486080 | 0.84 | GSK3B (0.66) | GSK3BGSK3ACDK2CYP1A2AAK1 | |
| SCHEMBL4483041 | 0.84 | GSK3B (0.67) | GSK3BGSK3ACDK2CYP1A2AAK1 | |
| SCHEMBL4485536 | 0.83 | HDAC6 (0.58) | GSK3BGSK3ACDK2CYP1A2AAK1 | |
| SCHEMBL4494232 | 0.83 | GSK3B (0.91) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4497828 | 0.83 | GSK3B (1.00) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4486435 | 0.83 | GSK3B (0.85) | GSK3BGSK3ACDK2CYP1A2HDAC1 | |
| SCHEMBL4480696 | 0.82 | AAK1 (0.57) | GSK3BGSK3ACDK2CYP1A2AAK1 | |
| SCHEMBL1462380 | 0.82 | GSK3B (1.00) | GSK3BGSK3ACDK2CYP1A2HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |