Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.57 |
| ▸ | HDAC2 | Q92769 | 8/20 | 0.57 |
| ▸ | HDAC8 | Q9BY41 | 8/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.52 |
| ▸ | GSK3B | P49841 | 6/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.49 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.49 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4494216 | 0.91 | HDAC1 (0.59) | HDAC1HDAC2HDAC8HDAC6GSK3B | |
| SCHEMBL4496581 | 0.84 | HDAC1 (0.65) | HDAC1HDAC2HDAC8HDAC6GSK3B | |
| SCHEMBL4500697 | 0.84 | GSK3B (0.67) | HDAC1HDAC2HDAC8HDAC6GSK3B | |
| SCHEMBL4492124 | 0.83 | HDAC6 (0.64) | HDAC1HDAC2HDAC8HDAC6GSK3B | |
| SCHEMBL4492088 | 0.82 | HDAC1 (0.71) | HDAC1HDAC2HDAC8HDAC6GSK3B | |
| SCHEMBL4498920 | 0.81 | HDAC1 (0.54) | HDAC1HDAC2HDAC8HDAC6GSK3B | |
| SCHEMBL4498073 | 0.81 | HDAC1 (0.72) | HDAC1HDAC2HDAC8HDAC6GSK3B | |
| SCHEMBL4480325 | 0.81 | GSK3B (0.54) | HDAC1HDAC2HDAC8HDAC6GSK3B | |
| SCHEMBL4494795 | 0.80 | GSK3B (0.55) | HDAC1HDAC2HDAC8HDAC6GSK3B | |
| SCHEMBL4503653 | 0.80 | HDAC1 (0.65) | HDAC1HDAC2HDAC8HDAC6GSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |