Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 9/20 | 0.67 |
| ▸ | HDAC1 | Q13547 | 7/20 | 0.64 |
| ▸ | HDAC2 | Q92769 | 7/20 | 0.64 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.64 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | MAP2K4 | P45985 | 1/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.57 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4503653 | 0.89 | HDAC1 (0.65) | GSK3BHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4559902 | 0.89 | GSK3B (0.63) | GSK3BHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4492124 | 0.89 | HDAC6 (0.64) | GSK3BHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4503805 | 0.86 | GSK3B (0.70) | GSK3BHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4496581 | 0.86 | HDAC1 (0.65) | GSK3BHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4492565 | 0.84 | HDAC1 (0.57) | GSK3BHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4497413 | 0.84 | HDAC1 (0.73) | GSK3BHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4490865 | 0.84 | HDAC1 (0.73) | GSK3BHDAC1HDAC2HDAC8HDAC6 | |
| SCHEMBL4497958 | 0.84 | GSK3B (0.77) | GSK3BHDAC1HDAC2HDAC8CYP1A2 | |
| SCHEMBL1461499 | 0.83 | HDAC1 (0.78) | GSK3BHDAC1HDAC2HDAC8CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |