Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 6/20 | 0.49 |
| ▸ | GSK3B | P49841 | 3/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.46 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.45 |
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4490306 | 0.89 | HDAC6 (0.52) | MAPK1SMN1; SMN2HDAC6FGFR1FGFR2 | |
| SCHEMBL4496312 | 0.89 | GSK3B (0.60) | HDAC6FGFR1FGFR2FGFR3ADORA3 | |
| SCHEMBL4503245 | 0.88 | ADORA3 (0.62) | HDAC6FGFR1FGFR2FGFR3ADORA3 | |
| SCHEMBL4490547 | 0.88 | GSK3B (0.58) | MAPK1SMN1; SMN2HDAC6FGFR1FGFR2 | |
| SCHEMBL4495236 | 0.86 | HDAC6 (0.63) | HDAC6FGFR1FGFR2FGFR3ADORA3 | |
| SCHEMBL4483701 | 0.86 | HDAC6 (0.55) | MAPK1SMN1; SMN2HDAC6FGFR1FGFR2 | |
| SCHEMBL4484485 | 0.85 | ADORA3 (0.49) | MAPK1SMN1; SMN2HDAC6FGFR1FGFR2 | |
| SCHEMBL4559708 | 0.85 | ADORA3 (0.58) | HDAC6FGFR1FGFR2FGFR3ADORA3 | |
| SCHEMBL4485505 | 0.85 | GSK3B (0.59) | HDAC6FGFR1FGFR2FGFR3ADORA3 | |
| SCHEMBL4493797 | 0.85 | AAK1 (0.58) | MAPK1HDAC6GSK3BGSK3AAAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632854-B2 | Aminoindazole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PFIZER ITALIA S.R.L. (IT) | 2009-12-15 | — | — | US | claimed |